|
KMID : 0606920110190040425
|
|
Biomolecules & Therapeutics
2011 Volume.19 No. 4 p.425 ~ p.430
|
|
|
Forsythiae Fructus and Its Active Component, Arctigenin, Provide Neuroprotection by Inhibiting Neuroinflammation
|
|
Park Ji-Ho
Hong Ye-Ji
Moon Eun-Jung
Kim Seul-A
Kim Sun-Yeou
|
|
|
Abstract
|
|
|
|
In this study, we found that Forsythiae fructus (FF) and one of its main compounds, arctigenin, signifi cantly inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Arctigenin also suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2, and inhibited the activation of extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. Moreover, it also reduced levels of proinfl ammatory cytokines, interleukin 1β, tumor necrosis factor α and prosta-glandin E2, and inhibited neuronal death in LPS-treated organotypic hippocampal cultures. Therefore, we suggest that arctigenin may confer a neuroprotective effect via the inhibition of neuroinfl ammation.
|
|
|
KEYWORD
|
|
|
Forsythiae fructus, Arctigenin, Microglia, Neuroprotection, Neuroinfl ammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|